Case report-malignant adenomyoepithelioma: A rare tumour of the breast

Published Date: 08th September 2021

Publication Authors: Stevenson J, Kiernan T, McKeown D, Innes H, Shaw M

Background:
We present a case report of a 45 year old female who presented with bilateral breast masses and one of these was shown to be a rare primary breast tumour. Malignant adenomyoepithelioma (AME-M) exhibits a classic biphasic proliferation of epithelial and myoepithelial cells, either or both of which have undergone malignant transformation. The published literature consists mainly of case reports with little guidance on oncological therapy.

Purpose:
To highlight the diagnostic challenge this rare entity presents, detail the histopathological features and comment on oncological aspects of treatment.

Methods:
We present the details of a case of malignant adenomyoepithelioma, highlighting the key diagnostic features and immunohistochemical staining profile. Differential diagnoses and approach to oncological management are briefly discussed.

Results:
Following initial histological assessment, an expert external opinion confirmed the original diagnosis. This case is of particular interest as it presented simultaneously to a contralateral invasive lobular breast carcinoma that complicated the treatment plan.

Conclusions:
AME-M is a rare tumour, often with a poor prognosis. Recognition of the biphasic luminal and myoepithelial components, supported by appropriate immunochemistry is important in making the correct diagnosis. AME-M is often resistant to chemotherapy and there is little published evidence to guide treatment after surgery.

Stevenson, J; Kiernan, T; McKeown, D; Innes, H; Shaw, M. (2021). Case Report - Malignant Adenomyoepithelioma: A Rare Tumour of the Breast. Journal of Pathology. 255 (S1), S.51

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