Photodynamic antimicrobial chemotherapy coupled with the use of the photosensitizers methylene blue and temoporfin as a potential novel treatment for Staphylococcus aureus in burn infections

Published Date: 04th May 2022

Publication Authors: Shokrollahi K

Winning poster presentation in the Research category at the BBA Annual Meeting, May 2022. Full conference programme available here: https://www.britishburnassociation.org/wp-content/uploads/2018/04/BBA-Bristol-4-6.5.22-Full-Programme-.pdf

Aim
This study aimed to assess the antimicrobial efficacy of methylene blue (MB) - and temoporfin-mediated PACT against both Gram+ve and Gram-ve bacterial species (namely S. aureus & P. aeruginosa) that are commonly isolated from burn infections.

Conclusions
Photodynamic therapy against bacteria is demonstrably effective

• PACT eradicated S. Aureus completely in this study.
• PACT was effective at reducing the quantity of P. Aeruginosa but not as effectively as against S. Aureus.

The role of PACT needs further investigation and has great potential in the future management of burn patients.

Recommendations
In light of this study, further research into the validity of PACT, coupled with the photosensitizers (such as Temoporfin), should be conducted in order to potentially develop alternative antimicrobial treatment regimes for burn and other wounds. The potential to successfully treat infecting and colonising organisms without antibiotics is an exciting development that warrants further study.

 

Hampden-Martin, A; Fothergill, J; El Mohtadi, M; Chambers, L; Slate, A J; Whitehead, K; Shokrollahi, K. (2022). Photodynamic antimicrobial chemotherapy coupled with the use of the photosensitizers methylene blue and temoporfin as a potential novel treatment for Staphylococcus aureus in burn infections. Conference poster from British Burns Association Annual Meeting, 4th-6th May 2022.

 

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