Prophylactic intravenous gentamicin with sedation-free cystoscopic injection of BoNT-A

Published Date: 02nd March 2023

Publication Authors: Chamsin A, Floyd Jr MS, Samsudin A, Omar A

Objectives
To determine whether administration of single dose prophylactic intravenous gentamicin prior to intravesical injection of botulinum toxin type A (BoNT-A) is associated with adverse extravesical neuromuscular effects in idiopathic overactive bladder syndrome.

Patients and methods
A retrospective analysis of 220 consecutive idiopathic overactive bladder patients following sedation-free flexible cystoscopic injection of intravesical BoNT-A. All patients received a single dose of intravenous gentamicin (160 mg) followed by 100-200 IU of BoNT-A. They were followed up at intervals to determine whether they had experienced any adverse extravesical neuromuscular side effe

Results
None of our patients developed adverse extravesical neuromuscular side effects from intravesical botulinum injections with concomitant administration of intravenous gentamicin.

Conclusion
Single dose intravenous gentamicin is safe to use as a prophylaxis for intravesical BoNT-A injections of 200 IU or below in idiopathic overactive bladder patients.

 

Napier-Hemy, TP; Chamsin, A; Floyd Jr; MS; Samsudin, A; Omar, AM. (2023). Prophylactic intravenous gentamicin with sedation-free cystoscopic injection of BoNT-A: No demonstrable adverse extravesical neuromuscular effects in a pilot safety study of 220 idiopathic overactive bladder patients. Journal of Clinical Urology. 16(2), pp.91-95. [Online]. Available at: https://doi.org/10.1177/20514158211016651 [Accessed 20 March 2023].

 

 

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