Proximal femur giant solitary plasmacytoma of bone: lessons learnt

Published Date: 19th July 2016

Publication Authors: Matar HE, Gudena R

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Solitary skeletal Plasmacytoma is a malignant plasma cell tumour that accounts for 3–5% of all monoclonal gammopathies. It presents as a single lytic lesion with clonal plasma cells in the vertebrae, ribs or pelvis, with low or no serum or urine M-protein. Bone marrow is not consistent with multiple myeloma, however, approximately 50% of cases progress to multiple myeloma over 4–5 years. Bone pain is the most common symptom; symptoms are usually of short duration because of the aggressive nature of the disease. Radiographically, solitary plasmacytoma appears as a sharply demarcated, purely lytic lesion without any surrounding reactive sclerosis. Diagnosis is usually confirmed by serum immunoelectrophoresis, bone scans, MRI, skeletal survey, bone...

Matar, HE; Mottram, C; Gudena, R. (2015). Proximal femur giant solitary plasmacytoma of bone: lessons learnt​ . BMJ Case Reports. Published online 10th August

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