Research Development

Staff Publications

 Small purple icon of a book with a magnifying glass on top  Staff Publications

Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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All publications by 'Clifford R'



Mersey and West Lancashire Teaching Hospitals NHS Trust – St Helens & Knowsley Staff

P066 Incisional hernia rate following laparoscopic anterior resection. Does extraction site matter?

Aim Incisional hernia are an established complication following abdominal surgery. There is limited data available on the relationship between formation of an incisional hernia and choice of extraction site for patients undergoing a laparoscopic anterior resection. This study aimed to determine the prevalence of incisional hernia following this operation and..

Published: 06/09/2022
Authors: Botzenhardt E, Clifford R, Rajaganeshan R

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0028 Acid ceramidase: A potential biomarker for locally advanced rectal cancer? (RSM Prize Winner)

Purpose/Background We have previously utilized proteomic and immuno-histochemical data to validate that high levels of acid ceramidase (AC) expression confers poorer neoadjuvant response in rectal cancer. Biological (siRNA, plasmid and CRISPR) AC manipulation altered radiosensitivity in-vitro. We aimed to assess the radiosensitising effect of pharmacological AC inhibitions and elucidate..

Published: 15/02/2022
Authors: Clifford R

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P083 IMPACT – ReCaP: rectal cancer management during the COVID-19 pandemic

Purpose/Background With enhanced strain on healthcare systems and avoidance of routine surgery and systemic therapy during the COVID-19 period due to increased morbidity and mortality alternative oncological approaches have been employed. We aimed to determine the variation in strategies adopted nationally across the United Kingdom (UK) and long-term associated..

Published: 15/02/2022
Authors: Clifford R

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Implant-Based Reconstruction following Mastectomy in Patients Who Have Had a Previous Breast Augmentation

Background Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared..

Published: 09/02/2022
Authors: Kiernan T, Clifford R, Chagla LS, Iqbal A

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Implant-Based Reconstruction following Mastectomy in Patients Who Have Had a Previous Breast Augmentation

Background Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared..

Published: 01/02/2022
Authors: Kiernan T, Clifford R, Chagla LS, Iqbal A

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Colorectal resections during the COVID-19 pandemic: a national survey of practice during first lockdown

Introduction The first wave of the COVID-19 pandemic led to an unprecedented time for the management of colorectal cancer, with uncertainty as to cancer-specific risks and the circumventing of gold standard oncological strategies. Our study aimed to acquire a snapshot of the practice of multidisciplinary team (MDT) management and variability..

Published: 23/12/2021
Authors: Rajput K, Clifford R, Rajaganeshan R, Kalaiselvan R

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P-O03 The Management of Gallbladder Polyps at a Single Trust: Are we compliant with European Guidelines?

Background Gallbladder polyps affect approximately 5% of the global population, with rates highest in those of Indian descent. 10% of polyps will have malignant potential based on their size or rapid growth rate, which are associated with a poor 5-year survival once advanced of less than 25%. As gallbladder polyps are common but..

Published: 16/12/2021
Authors: Jamieson E, Short C, Clifford R, Rajput K

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Reducing waiting lists for laparoscopic cholecystectomy: An intensive approach to aid COVID-19 recovery

Background Laparoscopic cholecystectomy is one of the most frequently performed operations in the United Kingdom, commonly due to symptomatic gallstones. Delay between diagnosis and definitive surgical intervention often leads to a significant readmission rate, growing financial burden and increased complexity of the ultimate surgical intervention. Resource reallocation and reduced operational..

Published: 14/06/2021
Authors: Clifford R, Rajput K, Naing CY, MacDonald K, Pantak T, Kaul A

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The effect on the surgeon of surgical complications: Are we doing enough to provide support?

Introduction Surgical complications have been shown to effect surgeons in a wide variety of domains, including psychological consequences and change in practice. A recent systematic review including over 8500 participants concluded that more formal support for surgical wellbeing after complications is required. We aimed to assess the effect of surgical complications..

Published: 16/07/2020
Authors: Clifford R, Kalaiselvan R

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Five-year local recurrence for breast cancer: The presentation of our local data

​Background Breast cancer is the most common cancer in women, affecting 1 in 8 worldwide. Overall survival has now reached 80% at 5 years, with improved targeted therapy. Although a large amount of data is collected for national audit, in the UK local recurrence rate is largely unknown.  Methods Retrospective analysis of prospectively collected..

Published: 25/04/2017
Authors: Clifford R, Antoniadis S, Chagla LS

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Specific mutations in KRAS codon 12

​ Background Activating mutations in KRAS have been suggested as potential predictive and prognostic biomarkers. However, the prognostic impact of specific point mutations remains less clear. This study assessed the prognostic impact of specific KRAS mutations on survival for patients with colorectal cancer. Methods Retrospective review of patients KRAS typed for..

Published: 24/04/2017
Authors: Clifford R

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St Helens Community Staff

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Knowsley Community Staff

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Halton Community Staff

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North West Boroughs Community Health Staff

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