Research Development
Staff Publications
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Staff Publications
Research Development
Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.
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Aim Incisional hernia are an established complication following abdominal surgery. There is limited data available on the relationship between formation of an incisional hernia and choice of extraction site for patients undergoing a laparoscopic anterior resection. This study aimed to determine the prevalence of incisional hernia following this operation and..
Published: | 06/09/2022 |
Authors: | Botzenhardt E, Clifford R, Rajaganeshan R |
Purpose/Background We have previously utilized proteomic and immuno-histochemical data to validate that high levels of acid ceramidase (AC) expression confers poorer neoadjuvant response in rectal cancer. Biological (siRNA, plasmid and CRISPR) AC manipulation altered radiosensitivity in-vitro. We aimed to assess the radiosensitising effect of pharmacological AC inhibitions and elucidate..
Published: | 15/02/2022 |
Authors: | Clifford R |
Purpose/Background With enhanced strain on healthcare systems and avoidance of routine surgery and systemic therapy during the COVID-19 period due to increased morbidity and mortality alternative oncological approaches have been employed. We aimed to determine the variation in strategies adopted nationally across the United Kingdom (UK) and long-term associated..
Published: | 15/02/2022 |
Authors: | Clifford R |
Background Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared..
Published: | 09/02/2022 |
Authors: | Kiernan T, Clifford R, Chagla LS, Iqbal A |
Background Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared..
Published: | 01/02/2022 |
Authors: | Kiernan T, Clifford R, Chagla LS, Iqbal A |
Introduction The first wave of the COVID-19 pandemic led to an unprecedented time for the management of colorectal cancer, with uncertainty as to cancer-specific risks and the circumventing of gold standard oncological strategies. Our study aimed to acquire a snapshot of the practice of multidisciplinary team (MDT) management and variability..
Published: | 23/12/2021 |
Authors: | Rajput K, Clifford R, Rajaganeshan R, Kalaiselvan R |
Background Gallbladder polyps affect approximately 5% of the global population, with rates highest in those of Indian descent. 10% of polyps will have malignant potential based on their size or rapid growth rate, which are associated with a poor 5-year survival once advanced of less than 25%. As gallbladder polyps are common but..
Published: | 16/12/2021 |
Authors: | Jamieson E, Short C, Clifford R, Rajput K |
Background Laparoscopic cholecystectomy is one of the most frequently performed operations in the United Kingdom, commonly due to symptomatic gallstones. Delay between diagnosis and definitive surgical intervention often leads to a significant readmission rate, growing financial burden and increased complexity of the ultimate surgical intervention. Resource reallocation and reduced operational..
Published: | 14/06/2021 |
Authors: | Clifford R, Rajput K, Naing CY, MacDonald K, Pantak T, Kaul A |
Introduction Surgical complications have been shown to effect surgeons in a wide variety of domains, including psychological consequences and change in practice. A recent systematic review including over 8500 participants concluded that more formal support for surgical wellbeing after complications is required. We aimed to assess the effect of surgical complications..
Published: | 16/07/2020 |
Authors: | Clifford R, Kalaiselvan R |
Background Breast cancer is the most common cancer in women, affecting 1 in 8 worldwide. Overall survival has now reached 80% at 5 years, with improved targeted therapy. Although a large amount of data is collected for national audit, in the UK local recurrence rate is largely unknown. Methods Retrospective analysis of prospectively collected..
Published: | 25/04/2017 |
Authors: | Clifford R, Antoniadis S, Chagla LS |
Background Activating mutations in KRAS have been suggested as potential predictive and prognostic biomarkers. However, the prognostic impact of specific point mutations remains less clear. This study assessed the prognostic impact of specific KRAS mutations on survival for patients with colorectal cancer. Methods Retrospective review of patients KRAS typed for..
Published: | 24/04/2017 |
Authors: | Clifford R |
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