Global Research Trends in Bladder Cancer Biomarkers: A Bibliometric Analysis

Published Date: 18th August 2025

Publication Authors: Gopi. P, Ishfaq. M, Shkoukani. ZW, Awsare. N, McCabe. J, Samsudin. A, Hughes. KE, Abdulmajed. MI

Abstract
Robotic flexible ureteroscopy (RFURS) has emerged as a novel approach to address the ergonomic challenges and technical limitations of conventional flexible ureteroscopy (FURS) for renal stone management. While FURS remains a cornerstone in treating nephrolithiasis, prolonged procedures contribute to surgeon fatigue, musculoskeletal strain, and increased radiation exposure. Despite growing adoption, the literature lacks a synthesis of the clinical benefits, cost-effectiveness, and long-term outcomes of RFURS compared to conventional approaches.

The objective of our study is to synthesize the existing evidence in the literature and produce a comprehensive systematic review of RFURS.

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Embase, and Cochrane (inception: June 2025) for clinical studies on RFURS. Meta-analysis used random-effects models for pooled estimates of stone-free rates (SFRs), operative times and complications. The risk of bias was assessed by the Newcastle-Ottawa Scale and the Cochrane risk tool.

Twelve studies (706 patients) were included. RFURS achieved a pooled SFR of 87.4% (95% confidence interval (CI): 82.7-92.0%), comparable to conventional FURS. Pooled operative time was 94.7 minutes (95% CI: 78.9-110.5), longer than conventional FURS. Complication rates were 10.6% (95% CI: 5.1-16.1%) similar to conventional FURS. Ergonomics were superior, with reduced surgeon fatigue and radiation exposure. Learning curves vary according to the robot platforms and early proficiency is noted among experienced endoscopists. Cost-effectiveness data were limited.

RFURS demonstrates non-inferior efficacy and safety to conventional FURS, with enhanced ergonomics and manageable learning curves. High heterogeneity and limited cost data necessitate larger comparative studies.

Gopi, P; Ishfaq, M; Shkoukani, ZW; Awsare, N; McCabe, J; Samsudin, A; Hughes, KE; Abdulmajed, M. (2025). Robotic Flexible Ureteroscopy: Systematic Review and Meta-Analysis of Surgical Efficacy, Safety and Ergonomic Outcomes. Cureus. 17(8), p.e90447. [Online]. Available at: https://doi.org/10.7759/cureus.90447 [Accessed 3 October 2025]

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