Exploring Knee Alignment: Demystifying Traditional and Emerging Approaches

Published Date: 01st September 2025

Publication Authors: Ben Nafa. W

Abstract:
Knee alignment plays a pivotal role in the outcomes of total knee replacement (TKR), influencing postoperative function, pain reduction, and long-term implant longevity. Over the past few decades, various knee alignment philosophies have been proposed to optimize surgical results, including the mechanical axis and kinematic alignment (KA). This review provides a comprehensive analysis of these alignment philosophies, evaluating their theoretical foundations, clinical outcomes, and impact on TKR outcomes, with a particular focus on the emerging role of KA.

The mechanical axis, traditionally regarded as the standard for TKR, ensures balance and stability by aligning the knee components along the mechanical axis of the lower limb. However, recent studies have questioned the universality of this approach, particularly considering the coronal plane alignment of the knee (CPAK), CPAK classification, and the growing popularity of the individualized knee arthroplasty concept. In contrast, KA seeks to restore the patient's prearthritic knee alignment, positioning the femoral and tibial components in accordance with the natural motion and geometry of the knee. Emerging evidence supports KA as a promising technique, demonstrating increased patient satisfaction and improved functional outcomes compared to traditional alignment methods.

Restricted kinematic alignment (rKA), a more constrained variant of KA, aims to preserve natural joint mechanics while preventing extreme alignments that could lead to instability or accelerated wear. While studies suggest that rKA may offer improved outcomes over the mechanical axis, its applicability and safety remain subjects of ongoing investigation.

This review critically evaluates various knee alignment philosophies, synthesizing contemporary evidence regarding their efficacy in TKR. It places a particular emphasis on the emerging technique of kinematic alignment (KA), highlighting its potential to offer superior outcomes in terms of patient satisfaction, functional recovery, and implant longevity. The findings suggest that, while no single alignment strategy is universally superior, a more individualized, patient-specific approach, particularly one that incorporates kinematic alignment (KA), may lead to enhanced TKR outcomes. This review underscores the need for continued research to refine these alignment strategies and optimize TKR results across a diverse patient population.

lmajee, M.; Ben Nafa, W.; Et al. (2025). Exploring Knee Alignment: Demystifying Traditional and Emerging Approaches. Cureus. 17(9), p.e91423. [Online]. Available at: https://doi.org/10.7759/cureus.91423 [Accessed 10 October 2025].

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