Research Development
Staff Publications
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Staff Publications
Research Development
Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.
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Abstract Capecitabine-induced subacute cutaneous lupus erythematosus is a documented but seemingly underappreciated phenomenon. We report our experience of two cases reviewed in a specialist immunochemotherapy dermatology clinic. A 73-year-old woman with a background of stage 4 oesophageal cancer presented with a rapidly progressive pruritic eruption. She had received one cycle of..
Published: | 05/07/2022 |
Authors: | Winters S, Hindle E |
Lavery, MJ; Forsysth, L; Forsyth, L. (2021). Cutaneous manifestations secondary to panitumumab therapy. Clinics in Dermatology. epub 08 Aug
Published: | 08/08/2021 |
Authors: | Lavery MJ, Hindle E |
Abstract Immune checkpoint inhibitors (ICIs) restore antitumour immunity and have revolutionized the treatment of several types of malignancy, including melanoma. However, these immunotherapeutic agents are often associated with immune‐related adverse events (irAEs), most commonly in the skin. Guidelines from the European Society for Medical Oncology recommend the use of..
Published: | 01/09/2020 |
Authors: | Hindle E |
Abstract Immune checkpoint inhibitors (ICIs) are immunomodulatory agents used in the treatment of an increasing number of malignancies. They inhibit tumour-induced immunosuppression and reactivate tumour-specific cytotoxic T lymphocytes resulting in control of malignant disease (Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12: 252-64). However, off-target..
Published: | 23/12/2019 |
Authors: | Hindle E |
Ultraviolet radiation predisposes to the development of nonmelanoma skin cancer (NMSC). Melanin safeguards the skin against this. This leads one to conjecture that patients with vitiligo are at a higher risk of developing skin malignancies. However, despite the lack of protective melanin and increased oxidative stress due to epidermal hydrogen..
Published: | 19/07/2016 |
Authors: | Hindle E |
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