Research Development

Staff Publications

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Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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All publications by 'Chagla LS'



Mersey and West Lancashire Teaching Hospitals NHS Trust – St Helens & Knowsley Staff

The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry-equivocal invasive breast cancer

Background and Aims Keratinocyte or non-melanoma skin cancer (NMSC) is the most common malignancy worldwide, encompassing basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). The mainstay of treatment for NMSC is excision. The likelihood of recurrence is directly related to achieving tumour-free margins. Just 1 per cent of BCCs..

Published: 25/07/2022
Authors: Chagla LS

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Feasibility of breast lesion localisation using Sirius Pintuition

Introduction Impalpable breast cancers can be localised using different techniques. Recently, magnetic seed localisation systems have been developed and shown to offer benefits over traditional wire guided techniques. This study aims to assess the feasibility of a new seed localisation device, Sirius Pintuition, at St Helen's and Knowsley NHS Trust.  ..

Published: 02/05/2022
Authors: Foster R, Bathla S, Harris O, Jois RHS, Kiernan T, Ray A, Chagla LS

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Formalised mentorship within oncoplastic breast surgery training - Is it indicated? A systematic review

Introduction Oncoplastic breast surgery places unique psychosocial and multi-disciplinary demands upon its trainees. As such, a healthy balance of personal and professional spheres are necessary to cultivate resiliency, emotional intelligence and self-awareness. Whilst the UK is a global leader in oncoplastic breast surgery training, no current trainee self-development scheme exists..

Published: 02/05/2022
Authors: Hunter-Smith A, Chagla LS

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Implant-Based Reconstruction following Mastectomy in Patients Who Have Had a Previous Breast Augmentation

Background Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared..

Published: 09/02/2022
Authors: Kiernan T, Clifford R, Chagla LS, Iqbal A

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Implant-Based Reconstruction following Mastectomy in Patients Who Have Had a Previous Breast Augmentation

Background Breast augmentation is the most commonly performed cosmetic procedure, and increasingly women in this group present with breast cancer or request risk-reducing surgery, but their optimal management is unclear. The authors explored the clinical and patient-reported outcomes of patients undergoing immediate implant-based breast reconstruction following previous augmentation and compared..

Published: 01/02/2022
Authors: Kiernan T, Clifford R, Chagla LS, Iqbal A

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Ethnicity and breast cancer in the UK: Where are we now?

Abstract Outcomes from breast cancer for women in the UK have improved significantly over recent decades. These gains are largely attributable to a combination of earlier diagnosis and access to treatments delivered to patients by the National Health Service irrespective of cost. Ethnic minority groups make up almost fifteen percent..

Published: 23/08/2021
Authors: Chagla LS

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P179. Comparing roll and magseed in management of impalpable breast lesions a single unit experience

Background Screening and the use of Neoadjuvant therapy has increased the number of breast lesions requiring localisation. The search for the ideal technique is still on. ROLL (Radioisotope guided Occult Lesion Localisation) is a reliable technique though not widely available, Magnetic Seed, is a new alternative. These two techniques have..

Published: 01/05/2021
Authors: Jois RHS, Pushdary KH, Patnam V, Gupta N, Kiernan T, Bathla S, Ray A, Harris O, Chagla LS

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14. Factors leading to the late diagnosis and poor outcomes of breast cancer in Matabeleland South and the Bulawayo Metropolitan Provinces in Zimbabwe

Introduction Breast cancer (BC) is the leading cause of female cancer deaths in Africa, and in Zimbabwe, >80% present with advanced disease. A grant-funded Needs Analysis (NA) was carried out to determine the causes for delayed diagnosis and poor BC outcomes in Bulawayo and Matabeleland South, and to investigate possible solutions...

Published: 01/05/2021
Authors: Chagla LS

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Loco-regional recurrence after skin and nipple-sparing mastectomy

Background Immediate autologous tissue breast reconstruction after skin- and nipple-sparing mastectomy, is becoming increasingly popular, while the benefits are evident, the concern is in leaving breast tissue under the skin envelope, which could potentially lead to a higher chance of recurrence. We aim to determine the incidence and study the..

Published: 12/12/2020
Authors: Shah A, Koshy O, Riogi B, Taghizadeh R, Bennett S, Chagla LS

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Management of the axilla following neoadjuvant chemotherapy - A change in practice

Introduction Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the axilla but most units are still treating the axilla with axillary lymph node dissection (ALND). Method(..

Published: 01/06/2020
Authors: Riogi B, Barker D, Harris O, , Chagla LS, Sripadam R

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P067: Assessment of burnout among breast surgeons in the United Kingdom

Background Burnout among physicians has gained significant attention recently because of its rising prevalence, and detrimental impact on quality of care and professional satisfaction. Little is known about burnout among breast surgeons in the United Kingdom (UK). We sought to identify factors that influence overall burnout and professional fulfilment in..

Published: 01/06/2020
Authors: Chagla LS

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Management of the axilla following neoadjuvant chemotherapy for breast cancer

Objectives Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the axilla but most units are still treating the axilla with axillary lymph node dissection (ALND). Materials..

Published: 04/04/2020
Authors: Riogi B, Barker D, Harris O, , Chagla LS

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Five-year local recurrence for breast cancer: The presentation of our local data

​Background Breast cancer is the most common cancer in women, affecting 1 in 8 worldwide. Overall survival has now reached 80% at 5 years, with improved targeted therapy. Although a large amount of data is collected for national audit, in the UK local recurrence rate is largely unknown.  Methods Retrospective analysis of prospectively collected..

Published: 25/04/2017
Authors: Clifford R, Antoniadis S, Chagla LS

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P118. Improving breast services – It's in the DNA

​ Introduction All breast referrals must be seen within 2 weeks. The sheer volume of referrals from primary care makes this a challenging target to achieve. It is therefore extremely important that clinics are utilised appropriately and that every effort is taken to minimise non-attendance. Current hospital policy is to re-appoint all..

Published: 19/07/2016
Authors: Chagla LS

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Breast cancer recurrence after ROLL lumpectomy

​ Background Very few literatures are available on the long term outcomes after Radioguided Occult Lesion Localisation (ROLL) guided lumpectomy for non palpable invasive breast cancer. We previously published a recurrence of 1.9% with median follow up of 33 months. This is the first observation reporting after a Ten year experience with ROLL...

Published: 19/07/2016
Authors: Jois RHS, Carini S, Harris O, Thind R, Desmond S, Ray A, Chagla LS, Bulgasim N,

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Impalpable Breast Cancer

​ Background:  The detection of impalpable breast cancer lesions is on the rise due to mass population screening. Radio-guided occult lesion localisation (ROLL) has recently been used in the management of early lesions while sentinel lymph node biopsy (SLNB) has been used to detect occult lymph node metastases. In order to..

Published: 19/07/2016
Authors: Herbert J, , Chagla LS, Desmond S, Galea M, Harris O, Ray A, Thind R, Jois RHS

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Sentinel lymph node biopsy

​ Background:  Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..

Published: 19/07/2016
Authors: Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S,

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ROLL Lumpectomy

​Background  Occult breast lesions are being successfully targeted by means of Radioactive-guided Occult Lesion Localization (ROLL). Several reports demonstrate suitability of ROLL technique to excise non-palpable breast lesions with immediate advantages. Aim  Evaluation of long-term outcomes after ROLL guided lumpectomy for early breast cancer. Materials and methods  A consecutive series..

Published: 19/07/2016
Authors: , Chagla LS, Desmond S, Harris O, Poonawala S, Thind R, Jois RHS

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Prediction of Non Sentinel Nodal Metastases After Positive Sentinel Lymph Node Biopsy for Early Breast Cancer – Burney Breast Unit Experience

Background: Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..

Published: 19/07/2016
Authors: Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S,

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St Helens Community Staff

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Halton Community Staff

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