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Research Development

Staff Publications

 Small purple icon of a book with a magnifying glass on top  Staff Publications

Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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All publications by 'Dawson J'


Mersey and West Lancashire Teaching Hospitals Staff

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St Helens and Knowsley Hospital Staff - Publications pre April 2024

Does methotrexate cause progressive fibrotic interstitial lung disease?

Abstract The aim is to evaluate the published evidence on whether methotrexate (MTX) use causes progressive fibrotic interstitial lung disease (fILD). This PRISMA-compliant systematic review has been registered electronically with PROSPERO 2018 ID CRD42018087838, Centre of review and dissemination at the University of York. A total of 29 articles met the inclusion..

Published: 29/01/2021
Authors: Dawson J, Quah E, Amoasii C, Mudawi T

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A panel of urinary proteins predicts active lupus nephritis and response to rituximab treatment

Objectives ∼30% of patients with SLE develop LN. Presence and/or severity of LN are currently assessed by renal biopsy, but biomarkers in serum or urine samples may provide an avenue for non-invasive routine testing. We aimed to validate a urinary protein panel for its ability to predict active renal involvement..

Published: 12/12/2020
Authors: Dawson J, McCaffrey P, Graham D, Williams E, Clewes A, Hornby N

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Rheumatoid arthritis related interstitial lung disease – improving outcomes over 25 years: a large multicentre UK study

Objective This study explores whether the prognosis of interstitial lung disease in rheumatoid arthritis (RA-ILD) has improved over time and assesses the potential influence of drug therapy in a large multicentre UK network. Methods We analysed data from 18 UK centres on patients meeting criteria for both RA and ILD diagnosed..

Published: 04/11/2020
Authors: Dawson J

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The impact of glucocorticoid initiation on the diagnostic accuracy of ultrasound

Background Temporal and axillary artery ultrasound (US) has been recommended by EULAR as the first-line investigation in patients with suspected giant cell arteritis (GCA).1 US is reported as having a 77% sensitivity and 96% specificity for GCA.1 However, these figures have largely been derived from studies carried out in specialist centres where..

Published: 01/06/2020
Authors: Sze JT, Dawson J

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Systematic literature review investigating whether methotrexate causes chronic pulmonary fibrosis

Conclusion Conclusion Our systematic literature review found high-quality unbiased evidence that methotrexate does not cause chronic pulmonary fibrosis in humans. In patients with RA, chronic pulmonary fibrosis is due to the underlying disease and not methotrexate. It is important to now address this across all disciplines and reject the hypothesis..

Published: 23/12/2019
Authors: Quah E, Amoasii C, Mudawi T, Dawson J

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SAT0130 Rheumatoid Arthritis Related Interstitial Lung Disease

​ Background  Rheumatoid arthritis (RA) is associated with interstitial lung disease (ILD). This is linked with an increased risk of early death from respiratory failure. There is debate on the relative safety of different disease modifying anti rheumatic drugs (DMARDs) in RA-ILD. Objectives  We have examined the effect of a range..

Published: 19/07/2016
Authors: Dawson J

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OP0037 Pulsed Cyclophosphamide in the Treatment

​ Background  There is little evidence base to guide clinicians in the management of patients with rheumatoid arthritis (RA) related interstitial lung disease (ILD). In the subgroup who have rapidly deteriorating respiratory function, pulsed cyclophosphamide has been advocated but no assessment of its efficacy has been published. The British Rheumatoid InterstitiaL..

Published: 19/07/2016
Authors: Dawson J

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OP0254 Association between Steroid Therapy and Survival

​ Background  Clinically relevant interstitial lung disease (ILD) is present in approximately 5% of patients with rheumatoid arthritis (RA). Traditionally, oral steroids have been used to treat this manifestation of RA, but no evidence base exists to support this. Indeed, concern has been raised that such an approach might be associated with..

Published: 19/07/2016
Authors: Dawson J

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Rheumatoid arthritis-related interstitial lung disease

​ Objectives The prevalence of interstitial lung disease (ILD) in RA is ∼5%. Previous work identified increasing age, active articular disease and articular damage as risk factors for RA-associated ILD (RA-ILD). The roles of high-resolution CT (HRCT) and lung function testing in defining the nature and extent of pulmonary involvement have recently..

Published: 19/07/2016
Authors: Dawson J

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Rheumatoid arthritis related interstitial lung disease

​ Background/Purpose Interstitial Lung Disease (ILD) is the commonest manifestation of lung disease in Rheumatoid Arthritis (RA) and the only complication reported to be increasing in prevalence, accounting for 6% of all RA deaths. High resolution computed tomography (HRCT) confirmed 25% of RA patients had radiological evidence of ILD. This study examines..

Published: 19/07/2016
Authors: Dawson J

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Association between immunosuppressive therapy and relative risk

​ Background RA is associated with clinically relevant interstitial lung disease (ILD) in around 5% of patients. A variety of immunosuppressive agents have been advocated in patients with RA-ILD, with very little evaluation of their comparative effectiveness. We have examined the influence of a range of immunosuppressives (ISP) on mortality in a..

Published: 19/07/2016
Authors: Dawson J

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Association Between Biologic Therapy and Survival

​ Background RA is associated with clinically relevant interstitial lung disease (ILD) in approximately 5% of patients. Concern has been expressed over the use of biologic therapies in patients with RA-ILD, with several reports of disease progression and death from accelerated respiratory failure. We have examined the association between different biologic therapies..

Published: 19/07/2016
Authors: Dawson J

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Association between steroid therapy and survival

​ Background Clinically relevant interstitial lung disease (ILD) is present in approximately 5% of patients with RA. Traditionally, oral steroids have been used to treat this manifestation of RA, but no evidence base exists to support this. Indeed, concern has been raised that such an approach might be associated with increased mortality..

Published: 19/07/2016
Authors: Dawson J

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Drug-induced interstitial lung disease

​ Abstract Drug-induced interstitial lung disease (ILD) is a rare but potentially fatal complication from the disease modifying drugs that we use for rheumatological conditions. Clinical presentation, prevalence and screening for MTX pneumonitis will be focussed upon. Diagnostic criteria for hypersensitivity pneumonitis will be reviewed. The talk will also give an..

Published: 19/07/2016
Authors: Dawson J

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Rheumatoid arthritis-related pulmonary fibrosis

​   Ennis, H; Dawson, J et al. (2014).  HLA-DRB1 associations with rheumatoid arthritis-related pulmonary fibrosis . Scandinavian Journal of Rheumatology. 43 (1), 75-76    

Published: 19/07/2016
Authors: Dawson J

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FRAX analysis

​ Background  Bone health is a significant problem with over 300,000 patients presenting with fragility fractures to hospitals in the UK each year resulting in 20% mortality and 50% disability. FRAX and Q fracture are two fracture risk-assessment tools available to use in the UK. FRAX is an important tool to assess 10-year fracture..

Published: 19/07/2016
Authors: Tayal V, Abernethy R, Clewes A, Dawson J, O'Rourke T

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Lung function tests and high resolution computed tomography

​ Background  Rheumatoid arthritis (RA) is associated with clinically relevant interstitial lung disease (ILD) in approximately 5% of patients. The natural history of the association has been shown to be poor: in a previous study mean survival was 3 years from diagnosis of RA-ILD [1]. The importance of high resolution computed tomography (HRCT) of..

Published: 19/07/2016
Authors: Dawson J

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Assessing the cardiovascular risk burden

​ Background  Rheumatoid arthritis (RA) is associated with the increased risk of cardiovascular (CV) mortality and morbidity. There are recommendations by European League against Rheumatism (EULAR) and National Institute for Health and Clinical Excellence (NICE) to include assessment of cardiovascular, osteoporosis, infection and depression risks annually. One of the ways CV..

Published: 19/07/2016
Authors: Patel V, , Abernethy R, Dawson J, Clewes A, Novak J, Cox A, Williams J, O'Rourke T

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Assessing osteoporosis risk

​ Background  Osteoporosis is a major cause of morbidity in patients with RA. It leads to fragility fractures frequently associated with disability, mortality and major financial and social impact. There is no clear guidance regarding when to screen for Osteoporosis in these group of patients who are at high risk compared..

Published: 19/07/2016
Authors: , Patel V, Abernethy R, Dawson J, Clewes A, Novak J, Cox A, Williams J, O'Rourke T

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Rituximab

​ Patel, V; Dawson, J and Patel, P. (2012).  Comment on: Non-infectious pulmonary toxicity of rituximab: a systematic review . Rheumatology. Published online 4th September

Published: 19/07/2016
Authors: Dawson J, Patel V

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Self-referral

​ Background:  Nurse Advice Lines have been a long accepted practice in Rheumatology. At St. Helens Hospital we expanded this to a Therapy Advice Line, and noticed an increasing tendency for self referral by our patients. From working parties on management of Early RA and Stable RA we emphasized our self..

Published: 19/07/2016
Authors: Clayton AM, Griffiths AE, Clewes A, Lynch M, Abernethy R, Dawson J

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St Helens Community Staff

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Knowsley Community Staff

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Halton Community Staff

North West Boroughs Community Health Staff

Practical Prescribing

​ Synopsis This book provides prescribing advice for medical and non-medical prescribers caring for adult patients with common musculoskeletal problems. It will be particularly useful for non-medical practitioners, including independent physiotherapy and podiatry prescribers. Reference is made to current prescribing law and accountability, and the principles of safe prescribing are clearly..

Published: 19/07/2016
Authors: Sephton R, Dawson J

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