Research Development
Staff Publications
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Staff Publications
Research Development
Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.
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Abstract The aim is to evaluate the published evidence on whether methotrexate (MTX) use causes progressive fibrotic interstitial lung disease (fILD). This PRISMA-compliant systematic review has been registered electronically with PROSPERO 2018 ID CRD42018087838, Centre of review and dissemination at the University of York. A total of 29 articles met the inclusion..
Published: | 29/01/2021 |
Authors: | Dawson J, Quah E, Amoasii C, Mudawi T |
Objectives ∼30% of patients with SLE develop LN. Presence and/or severity of LN are currently assessed by renal biopsy, but biomarkers in serum or urine samples may provide an avenue for non-invasive routine testing. We aimed to validate a urinary protein panel for its ability to predict active renal involvement..
Published: | 12/12/2020 |
Authors: | Dawson J, McCaffrey P, Graham D, Williams E, Clewes A, Hornby N |
Objective This study explores whether the prognosis of interstitial lung disease in rheumatoid arthritis (RA-ILD) has improved over time and assesses the potential influence of drug therapy in a large multicentre UK network. Methods We analysed data from 18 UK centres on patients meeting criteria for both RA and ILD diagnosed..
Published: | 04/11/2020 |
Authors: | Dawson J |
Background Temporal and axillary artery ultrasound (US) has been recommended by EULAR as the first-line investigation in patients with suspected giant cell arteritis (GCA).1 US is reported as having a 77% sensitivity and 96% specificity for GCA.1 However, these figures have largely been derived from studies carried out in specialist centres where..
Published: | 01/06/2020 |
Authors: | Sze JT, Dawson J |
Conclusion Conclusion Our systematic literature review found high-quality unbiased evidence that methotrexate does not cause chronic pulmonary fibrosis in humans. In patients with RA, chronic pulmonary fibrosis is due to the underlying disease and not methotrexate. It is important to now address this across all disciplines and reject the hypothesis..
Published: | 23/12/2019 |
Authors: | Quah E, Amoasii C, Mudawi T, Dawson J |
Background Rheumatoid arthritis (RA) is associated with interstitial lung disease (ILD). This is linked with an increased risk of early death from respiratory failure. There is debate on the relative safety of different disease modifying anti rheumatic drugs (DMARDs) in RA-ILD. Objectives We have examined the effect of a range..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background There is little evidence base to guide clinicians in the management of patients with rheumatoid arthritis (RA) related interstitial lung disease (ILD). In the subgroup who have rapidly deteriorating respiratory function, pulsed cyclophosphamide has been advocated but no assessment of its efficacy has been published. The British Rheumatoid InterstitiaL..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background Clinically relevant interstitial lung disease (ILD) is present in approximately 5% of patients with rheumatoid arthritis (RA). Traditionally, oral steroids have been used to treat this manifestation of RA, but no evidence base exists to support this. Indeed, concern has been raised that such an approach might be associated with..
Published: | 19/07/2016 |
Authors: | Dawson J |
Objectives The prevalence of interstitial lung disease (ILD) in RA is ∼5%. Previous work identified increasing age, active articular disease and articular damage as risk factors for RA-associated ILD (RA-ILD). The roles of high-resolution CT (HRCT) and lung function testing in defining the nature and extent of pulmonary involvement have recently..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background/Purpose Interstitial Lung Disease (ILD) is the commonest manifestation of lung disease in Rheumatoid Arthritis (RA) and the only complication reported to be increasing in prevalence, accounting for 6% of all RA deaths. High resolution computed tomography (HRCT) confirmed 25% of RA patients had radiological evidence of ILD. This study examines..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background RA is associated with clinically relevant interstitial lung disease (ILD) in around 5% of patients. A variety of immunosuppressive agents have been advocated in patients with RA-ILD, with very little evaluation of their comparative effectiveness. We have examined the influence of a range of immunosuppressives (ISP) on mortality in a..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background RA is associated with clinically relevant interstitial lung disease (ILD) in approximately 5% of patients. Concern has been expressed over the use of biologic therapies in patients with RA-ILD, with several reports of disease progression and death from accelerated respiratory failure. We have examined the association between different biologic therapies..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background Clinically relevant interstitial lung disease (ILD) is present in approximately 5% of patients with RA. Traditionally, oral steroids have been used to treat this manifestation of RA, but no evidence base exists to support this. Indeed, concern has been raised that such an approach might be associated with increased mortality..
Published: | 19/07/2016 |
Authors: | Dawson J |
Abstract Drug-induced interstitial lung disease (ILD) is a rare but potentially fatal complication from the disease modifying drugs that we use for rheumatological conditions. Clinical presentation, prevalence and screening for MTX pneumonitis will be focussed upon. Diagnostic criteria for hypersensitivity pneumonitis will be reviewed. The talk will also give an..
Published: | 19/07/2016 |
Authors: | Dawson J |
Ennis, H; Dawson, J et al. (2014). HLA-DRB1 associations with rheumatoid arthritis-related pulmonary fibrosis . Scandinavian Journal of Rheumatology. 43 (1), 75-76
Published: | 19/07/2016 |
Authors: | Dawson J |
Background Bone health is a significant problem with over 300,000 patients presenting with fragility fractures to hospitals in the UK each year resulting in 20% mortality and 50% disability. FRAX and Q fracture are two fracture risk-assessment tools available to use in the UK. FRAX is an important tool to assess 10-year fracture..
Published: | 19/07/2016 |
Authors: | Tayal V, Abernethy R, Clewes A, Dawson J, O'Rourke T |
Background Rheumatoid arthritis (RA) is associated with clinically relevant interstitial lung disease (ILD) in approximately 5% of patients. The natural history of the association has been shown to be poor: in a previous study mean survival was 3 years from diagnosis of RA-ILD [1]. The importance of high resolution computed tomography (HRCT) of..
Published: | 19/07/2016 |
Authors: | Dawson J |
Background Rheumatoid arthritis (RA) is associated with the increased risk of cardiovascular (CV) mortality and morbidity. There are recommendations by European League against Rheumatism (EULAR) and National Institute for Health and Clinical Excellence (NICE) to include assessment of cardiovascular, osteoporosis, infection and depression risks annually. One of the ways CV..
Published: | 19/07/2016 |
Authors: | Patel V, , Abernethy R, Dawson J, Clewes A, Novak J, Cox A, Williams J, O'Rourke T |
Background Osteoporosis is a major cause of morbidity in patients with RA. It leads to fragility fractures frequently associated with disability, mortality and major financial and social impact. There is no clear guidance regarding when to screen for Osteoporosis in these group of patients who are at high risk compared..
Published: | 19/07/2016 |
Authors: | , Patel V, Abernethy R, Dawson J, Clewes A, Novak J, Cox A, Williams J, O'Rourke T |
Patel, V; Dawson, J and Patel, P. (2012). Comment on: Non-infectious pulmonary toxicity of rituximab: a systematic review . Rheumatology. Published online 4th September
Published: | 19/07/2016 |
Authors: | Dawson J, Patel V |
Background: Nurse Advice Lines have been a long accepted practice in Rheumatology. At St. Helens Hospital we expanded this to a Therapy Advice Line, and noticed an increasing tendency for self referral by our patients. From working parties on management of Early RA and Stable RA we emphasized our self..
Published: | 19/07/2016 |
Authors: | Clayton AM, Griffiths AE, Clewes A, Lynch M, Abernethy R, Dawson J |
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Synopsis This book provides prescribing advice for medical and non-medical prescribers caring for adult patients with common musculoskeletal problems. It will be particularly useful for non-medical practitioners, including independent physiotherapy and podiatry prescribers. Reference is made to current prescribing law and accountability, and the principles of safe prescribing are clearly..
Published: | 19/07/2016 |
Authors: | Sephton R, Dawson J |