Research Development

Staff Publications

 Small purple icon of a book with a magnifying glass on top  Staff Publications

Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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All publications by 'Shuker K'



Mersey and West Lancashire Teaching Hospitals NHS Trust – St Helens & Knowsley Staff

A second update on mapping the human genetic architecture of COVID-19

Extract Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development1,2. Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19..

Published: 07/09/2023
Authors: Shuker K, Tridente A

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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

Abstract The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate..

Published: 18/01/2022
Authors: Tridente A, Shuker K

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Genetic mechanisms of critical illness in COVID-19

Abstract Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244..

Published: 03/03/2021
Authors: Tridente A, Shuker K

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St Helens Community Staff

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Knowsley Community Staff

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can..

Published: 17/05/2023
Authors: Shuker K, Tridente A

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Halton Community Staff

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North West Boroughs Community Health Staff

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