Research Development
Staff Publications
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Staff Publications
Research Development
Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.
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Introduction Existing randomised controlled trials assessing the safety and efficacy of left atrial appendage occlusion (LAAO) in atrial fibrillation (AF) were of relatively small sample size, or included patients who could receive oral anticoagulant treatment after device implantation. We compared the outcomes of patients with newly diagnosed AF who received..
Published: | 02/02/2024 |
Authors: | Elsheikh S, Irving G, Hill AM, Abdul-Rahim A |
Introduction Stroke is a major complication of atrial fibrillation (AF). About 25% of ischaemic stroke are cardio-embolic in origin; AF is the most common cause of those.1 Nonvalvular AF carries a 5-fold increased risk of stroke,2 while AF related to mitral stenosis increases the risk of stroke by 20-fold.3 The attributable..
Published: | 31/10/2023 |
Authors: | Elsheikh S, Hill AM, Irving G, Abdul-Rahim A |
Extract New-onset cardiovascular complications following an ischaemic stroke, hereafter termed stroke–heart syndrome, are a major medical challenge of the 21st century, yet are under-recognized and under-researched.1,2 Acutely, stroke–heart syndrome associates with poorer functional prognosis and increased mortality following stroke.3 In the long term, stroke–heart syndrome associates with..
Published: | 28/06/2023 |
Authors: | Hill AM |
Introduction People with atrial fibrillation (AF) frequently have competing mechanisms for ischaemic stroke, including extracranial carotid atherosclerosis. The objective of this study was to determine associations between use of oral anticoagulants (OACs) plus antiplatelet agents (APA) after ischaemic stroke and outcomes for patients with AF and carotid artery disease. Methods..
Published: | 24/01/2023 |
Authors: | Hill AM |
Introduction Improving risk prediction models for adverse outcomes following stroke, such as atrial fibrillation (AF), recurrent stroke, and cognitive impairment and dementia, would help target secondary prevention and other intervention strategies. The primary aim of the Liverpool-Heart And bRain Project (L-HARP) is to establish a prospective cohort study of adults..
Published: | 17/01/2023 |
Authors: | Hill AM, Choi S, Elsheikh S, Sagris D, Alobaida M |
Introduction Stroke is one of the leading causes of mortality and morbidity globally. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic proportions. AF is associated with a five-fold increase in risk of stroke. Strokes caused by AF more often are fatal or..
Published: | 08/01/2023 |
Authors: | Hill AM, Abdul-Rahim A |
Introduction Endovascular thrombectomy (EVT) is associated with good clinical outcomes in patients with ischemic stroke, but the impact of EVT on clinical outcomes in patients with ischemic stroke with and without atrial fibrillation (AF), and the effect of adjunctive pharmacological therapies with EVT, remains unclear. Areas covered The goal of..
Published: | 01/01/2023 |
Authors: | Hill AM |
Objectives Endovascular thrombectomy (EVT) is associated with good clinical outcomes in ischaemic stroke, but the risk of intracerebral haemorrhage (ICH) and mortality remains common following ischaemic stroke. The effect of concomitant atrial fibrillation (AF) on clinical outcomes following acute ischaemic stroke in patients receiving EVT remains unclear. The aim is..
Published: | 05/12/2022 |
Authors: | Hill AM, Harrison S, Lip G |
Background Newly diagnosed cardiovascular complications post-stroke, termed stroke-heart syndrome, are common and associate with worsened prognosis. Purpose To investigate the sex-specific incidence and 5-year major adverse cardiovascular events following stroke-heart syndrome, stratified by pre-existing risk factors (sex, age, obesity, hypertension, type 2 diabetes mellitus, and high LDL cholesterol). Methods A retrospective..
Published: | 03/10/2022 |
Authors: | Hill AM |
Background The risk of major adverse cardiovascular events is substantially increased following a stroke. Although exercise-based cardiac rehabilitation has been shown to improve prognosis following cardiac events, it is not part of routine care for people following a stroke. We, therefore, investigated the association between cardiac rehabilitation and major adverse..
Published: | 31/03/2022 |
Authors: | Hill AM |
Objectives Identifying instances where medications have been discontinued due to an adverse/allergic reaction however the patients’ allergy status has not been updated appropriately. Data were evaluated in an established electronic prescribing and medicines administration system within a medium-sized teaching hospital. Methods Details of all medications stopped due to allergic..
Published: | 30/03/2022 |
Authors: | Logan B, Hill AM |
This document supersedes the existing professional multisociety consensus guidance published in 2015. It has been produced in order to respond to the considerable volume of relevant new high-quality trial evidence that has become available since September 2015. It should be emphasised that this document remains applicable to all constituent nations of the..
Published: | 03/09/2021 |
Authors: | Hill AM |
Essa, H; Hill, AM; Lip, GYH. (2021). Atrial Fibrillation and Stroke. Cardiac Electrophysiology Clinics. 13 (1), 243-255.
Published: | 16/03/2021 |
Authors: | Hill AM |
Abstract Atrial fibrillation (AF) is the most common cardiac arrythmia and a major cause of stroke, heart failure, sudden death, and cardiovascular morbidity. AF increases risk of thromboembolic stroke via stasis in the left atrium and subsequent embolization to the brain. In patients with acute ischemic stroke, it is essential..
Published: | 01/03/2021 |
Authors: | Hill AM |
Extract Stroke is a leading cause of death and disability worldwide. Risk factors such as advancing age, hypertension, cigarette smoking, atrial fibrillation (AF), diabetes mellitus and prior cardiovascular disease are well established and provide significant opportunities through public health policy to reduce both the disease burden and the socio-economic cost..
Published: | 04/04/2020 |
Authors: | Hill AM |
Background and Aims High-quality care of stroke patients delivered on Hyperacute Stroke Units (HASUs) has been one of the primary contributors to reductions in stroke mortality and institutionalisation. Effective multidisciplinary management of the unwell stroke patient is an essential skill unique to this environment. Simulation training is a well-recognised means..
Published: | 10/07/2018 |
Authors: | Attwood K, Hill AM, Rowson M, Seed A |
Challenge To minimise delays to hyper-acute stroke unit (HASU) admission for all stroke patients. Solution We developed a system for checking and reviewing data. This governance process aims to help team members understand why there may be delays in getting patients to the stroke unit. Hill, AM. (2017). Clinical Governance and..
Published: | 13/11/2017 |
Authors: | Hill AM |
Hill, AM. (1 Feb 2017). Using Stroke Sentinel Audit Data to drive quality improvement. Royal College of Physicians Commentary Magazine
Published: | 01/02/2017 |
Authors: | Hill AM |
Extract Being admitted with a suspected stroke can be stressful and bewildering for stroke patients and their families. A simple way to alleviate this and provide high quality stroke care is to try to ensure that patients who have had a suspected stroke are admitted to a specialist ward, and..
Published: | 29/11/2016 |
Authors: | Hill AM |
Introduction Early initial multi-disciplinary therapy assessment following stroke admission is important to establish baseline function, engage patients and families, manage expectations and set realistic rehabilitation and treatment goals. Bray et al established that there are significant variations in assessment time according to time of admission and day of admission. We..
Published: | 21/11/2016 |
Authors: | Hill AM |
Introduction Intracerebral haemorrhage is one of the most feared complications of delivering thrombolysis therapy. Variable complication rates are quoted for symptomatic haemorrhage post-thrombolysis, reflecting difficulty establishing whether the extent of haemorrhage, or the original infarction was responsible for the eventual outcome. National datasets such as the Stroke Sentinel National..
Published: | 21/11/2016 |
Authors: | Hill AM |
Parallet Session 2A: High Scoring Abstract Introduction In 2015, Smith et al analysed the Stroke Sentinel National Audit Programme dataset to produce a risk assessment tool for predicting 7 and 30 day mortality and the prevalence of stroke associated pneumonia (SAP). In our study we analysed our Trust’s stroke population over the..
Published: | 21/11/2016 |
Authors: | Hill AM |
Summary Our team developed a mathematical simulation of a stroke unit, allowing us to demonstrate the optimal size and configuration for a stroke unit. The model utilised existing known inputs: including the number of strokes, stroke ‘mimics’, TIAs, and optionally the presence of medical outliers on the stroke unit. For..
Published: | 27/10/2016 |
Authors: | Hill AM |
Summary The Stroke Sentinal National Audit Programme Dataset contains valuable operational data but is limited by its lag time to reporting. We have developed a realtime data dashboard which enables SSNAP data to be used to study the performance of our unit live. Data is entered onto the dashboard by..
Published: | 27/10/2016 |
Authors: | Hill AM |
Morris and colleagues did not discuss how substantial financial investment in services affected their results. The London stroke strategy was supported by an additional £23m (€28.8m; $37.3m) in funding.2 The cost improvement programme highlighted the need for an extra £13m investment in hyperacute stroke units to provide the imaging and..
Published: | 19/07/2016 |
Authors: | Hill AM |
Hill, AM. (2016). Using Stroke Sentinel National Audit Data To Deliver Organisational Change - A keynote speech to the NI Stroke Forum. 5th NIMAST Northern Ireland Stroke Conference. 17 May
Published: | 17/05/2016 |
Authors: | Hill AM |
Hill, AM. (2016). Challenging Hunt on Strokes (Letter). The Times. 17 January.
Published: | 17/01/2016 |
Authors: | Hill AM |
Summary Our team developed a mathematical simulation of a stroke unit, allowing us to demonstrate the optimal size and configuration for a stroke unit. The model utilised existing known inputs: including the number of strokes, stroke ‘mimics’, TIAs, and optionally the presence of medical outliers on the stroke unit. For..
Published: | 24/10/2015 |
Authors: | Hill AM |
Summary The Stroke Sentinal National Audit Programme Dataset contains valuable operational data but is limited by its lag time to reporting. We have developed a realtime data dashboard which enables SSNAP data to be used to study the performance of our unit live. Data is entered onto the dashboard..
Published: | 23/10/2015 |
Authors: | Hill AM |
Extract Morris and colleagues did not discuss how substantial financial investment in services affected their results.1 The London stroke strategy was supported by an additional £23m (€28.8m; $37.3m) in funding.2 The cost improvement programme highlighted the need for an extra £13m investment in hyperacute stroke units to Hill, AM. (2014). Centralising..
Published: | 23/09/2014 |
Authors: | Hill AM |
Introduction Stroke is a major complication of atrial fibrillation (AF). About 25% of ischaemic stroke are cardio-embolic in origin; AF is the most common cause of those.1 Nonvalvular AF carries a 5-fold increased risk of stroke,2 while AF related to mitral stenosis increases the risk of stroke by 20-fold.3 The attributable..
Published: | 31/10/2023 |
Authors: | Elsheikh S, Hill AM, Irving G, Abdul-Rahim A |
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