Research Development

Staff Publications

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Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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All publications by 'Marshall E'



Mersey and West Lancashire Teaching Hospitals NHS Trust – St Helens & Knowsley Staff

Adjuvant therapy with pegylated interferon-alfa2b vs observation in stage II B/C patients

Background Subgroup analyses of two large EORTC adjuvant interferon-alpha2b (IFNα-2b) vs observation randomised trials demonstrated that a treatment benefit was observed only in patients with an ulcerated melanoma without palpable nodes (hazard ratio [HR] for recurrence-free survival [RFS] was 0.69). This was confirmed by a meta-analysis of 15 adjuvant..

Published: 01/07/2020
Authors: Marshall E

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Adjuvant bevacizumab for melanoma patients at high risk of recurrence

​Background Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor (VEGF) shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of recurrence. Patients and Methods Patients with resected AJCC stage IIB, IIC and III cutaneous..

Published: 24/07/2018
Authors: Marshall E

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Adjuvant bevacizumab in patients with melanoma

​ Background Bevacizumab, a monoclonal antibody that targets VEGF, has shown restricted activity in patients with advanced melanoma. We aimed to assess the role of bevacizumab as adjuvant treatment for patients with resected melanoma at high risk of recurrence. We report results from the preplanned interim analysis. Methods We did a..

Published: 19/07/2016
Authors: Marshall E

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Colorectal Cancer Risk

​ Abstract We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10−10), 11q13.4 (rs3824999,..

Published: 19/07/2016
Authors: Abbas M, Marshall E

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Carcinoma with Unknown Primary

​ Abstract Widespread metastatic disease with no obvious primary on initial investigations is a diagnostic challenge often encountered by radiologists. Carcinoma of unknown primary origin (CUP) forms a heterogeneous group of cancers constituting approximately 3-5% of new cancers and amongst the top 10 causes of cancer-related deaths worldwide. A radiologist is often..

Published: 19/07/2016
Authors: , Marshall E, Thind R

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St Helens Community Staff

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Knowsley Community Staff

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Halton Community Staff

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North West Boroughs Community Health Staff

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