Research Development
Staff Publications
Sign in using NHS OpenAthens to access our Knowlege Alerts as well as other useful online resources.
Staff Publications
Research Development
Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.
Had something published and it's not included here? Let us know by completing this form.
Resources pertaining to writing for a publication and how to get published can be found by clicking here.
Introduction Lobular carcinomas account for around 10% of invasive breast cancers. Accuracy of pre-operative evaluation can be troublesome. NICE guidelines recommend MRI "to assess the tumour size if breast-conserving surgery is being considered for invasive lobular cancer". However, each additional investigation introduces cost and potentially prolongs the treatment pathway, which is..
Published: | 02/05/2022 |
Authors: | Wadsworth P, Rimmer L, Sepesiova L, Fong J, Kiernan T, Harris O |
Introduction Impalpable breast cancers can be localised using different techniques. Recently, magnetic seed localisation systems have been developed and shown to offer benefits over traditional wire guided techniques. This study aims to assess the feasibility of a new seed localisation device, Sirius Pintuition, at St Helen's and Knowsley NHS Trust. ..
Published: | 02/05/2022 |
Authors: | Foster R, Bathla S, Harris O, Jois RHS, Kiernan T, Ray A, Chagla LS |
Background Screening and the use of Neoadjuvant therapy has increased the number of breast lesions requiring localisation. The search for the ideal technique is still on. ROLL (Radioisotope guided Occult Lesion Localisation) is a reliable technique though not widely available, Magnetic Seed, is a new alternative. These two techniques have..
Published: | 01/05/2021 |
Authors: | Jois RHS, Pushdary KH, Patnam V, Gupta N, Kiernan T, Bathla S, Ray A, Harris O, Chagla LS |
Introduction Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the axilla but most units are still treating the axilla with axillary lymph node dissection (ALND). Method(..
Published: | 01/06/2020 |
Authors: | Riogi B, Barker D, Harris O, , Chagla LS, Sripadam R |
Objectives Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the axilla but most units are still treating the axilla with axillary lymph node dissection (ALND). Materials..
Published: | 04/04/2020 |
Authors: | Riogi B, Barker D, Harris O, , Chagla LS |
Neo-adjuvant chemo & hormone therapy is very effective in reducing the size of the primary breast cancer: this may result into a substantial response, hence the need to localise a non-palpable lesion. A variety of localisation techniques are used to target surgical removal of these subclinical lesions i.e., Wire marker,..
Published: | 19/07/2016 |
Authors: | Jois RHS, Harris O, |
Background Very few literatures are available on the long term outcomes after Radioguided Occult Lesion Localisation (ROLL) guided lumpectomy for non palpable invasive breast cancer. We previously published a recurrence of 1.9% with median follow up of 33 months. This is the first observation reporting after a Ten year experience with ROLL...
Published: | 19/07/2016 |
Authors: | Jois RHS, Carini S, Harris O, Thind R, Desmond S, Ray A, Chagla LS, Bulgasim N, |
Background: Neo-adjuvant chemotherapy is being increasingly used for breast cancer. MRI is used for assessing tumour response. Literature on correlation of pathologic response and MRI response is scanty. Aim: Can a pre-operative MRI predict pathologic response of breast cancer to neo-adjuvant chemotherapy? Methods: A consecutive series of patients with invasive..
Published: | 19/07/2016 |
Authors: | , Jois RHS, Harris O, Pennick M |
Background: We have used Radioisotope Occult Lesion Localization (ROLL) of breast lesions at our unit since 2002. Literature reports failure rates of 4 - 10% for Wire Guided Localisation (WGL). Ours is the first reporting of the difficulties with ROLL (UK) and lessons learnt from it. Method: A consecutive series of patients underwent..
Published: | 19/07/2016 |
Authors: | , Carini S, Harris O, Thind R, Desmond S, Jois RHS |
Background: The detection of impalpable breast cancer lesions is on the rise due to mass population screening. Radio-guided occult lesion localisation (ROLL) has recently been used in the management of early lesions while sentinel lymph node biopsy (SLNB) has been used to detect occult lymph node metastases. In order to..
Published: | 19/07/2016 |
Authors: | Herbert J, , Chagla LS, Desmond S, Galea M, Harris O, Ray A, Thind R, Jois RHS |
Background: Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..
Published: | 19/07/2016 |
Authors: | Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S, |
Background: Occurrence of metastatic disease to breast (secondary breast cancer) in both women and men is rare, constituting 0.5-6% of breast malignancy. In addition to systematic history taking and clinical examination, early diagnosis of secondary breast cancer demands vigilance by radiologists to distinguish subtle disparities between much commoner primary breast..
Published: | 19/07/2016 |
Authors: | Kulkarni T, , Jois RHS, Harris O, Thind R |
Background Occult breast lesions are being successfully targeted by means of Radioactive-guided Occult Lesion Localization (ROLL). Several reports demonstrate suitability of ROLL technique to excise non-palpable breast lesions with immediate advantages. Aim Evaluation of long-term outcomes after ROLL guided lumpectomy for early breast cancer. Materials and methods A consecutive series..
Published: | 19/07/2016 |
Authors: | , Chagla LS, Desmond S, Harris O, Poonawala S, Thind R, Jois RHS |
Background: Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..
Published: | 19/07/2016 |
Authors: | Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S, |
No results for this category.
No results for this category.
No results for this category.
No results for this category.