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Research Development

Staff Publications

 Small purple icon of a book with a magnifying glass on top  Staff Publications

Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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All publications by 'Harris O'


Mersey and West Lancashire Teaching Hospitals Staff

St Helens and Knowsley Hospital Staff - Publications pre April 2024

Influence of MRI use on surgical outcomes in lobular breast cancer

Introduction Lobular carcinomas account for around 10% of invasive breast cancers. Accuracy of pre-operative evaluation can be troublesome. NICE guidelines recommend MRI "to assess the tumour size if breast-conserving surgery is being considered for invasive lobular cancer". However, each additional investigation introduces cost and potentially prolongs the treatment pathway, which is..

Published: 02/05/2022
Authors: Wadsworth P, Rimmer L, Sepesiova L, Fong J, Kiernan T, Harris O

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Feasibility of breast lesion localisation using Sirius Pintuition

Introduction Impalpable breast cancers can be localised using different techniques. Recently, magnetic seed localisation systems have been developed and shown to offer benefits over traditional wire guided techniques. This study aims to assess the feasibility of a new seed localisation device, Sirius Pintuition, at St Helen's and Knowsley NHS Trust.  ..

Published: 02/05/2022
Authors: Foster R, Bathla S, Harris O, Jois RHS, Kiernan T, Ray A, Chagla LS

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P179. Comparing roll and magseed in management of impalpable breast lesions a single unit experience

Background Screening and the use of Neoadjuvant therapy has increased the number of breast lesions requiring localisation. The search for the ideal technique is still on. ROLL (Radioisotope guided Occult Lesion Localisation) is a reliable technique though not widely available, Magnetic Seed, is a new alternative. These two techniques have..

Published: 01/05/2021
Authors: Jois RHS, Pushdary KH, Patnam V, Gupta N, Kiernan T, Bathla S, Ray A, Harris O, Chagla LS

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Management of the axilla following neoadjuvant chemotherapy - A change in practice

Introduction Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the axilla but most units are still treating the axilla with axillary lymph node dissection (ALND). Method(..

Published: 01/06/2020
Authors: Riogi B, Barker D, Harris O, , Chagla LS, Sripadam R

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Management of the axilla following neoadjuvant chemotherapy for breast cancer

Objectives Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from breast conservation surgery. The effect of neoadjuvant chemotherapy (NAC) has also been observed in the axilla but most units are still treating the axilla with axillary lymph node dissection (ALND). Materials..

Published: 04/04/2020
Authors: Riogi B, Barker D, Harris O, , Chagla LS

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ROLL after neo adjuvant treatment

​ Neo-adjuvant chemo & hormone therapy is very effective in reducing the size of the primary breast cancer: this may result into a substantial response, hence the need to localise a non-palpable lesion. A variety of localisation techniques are used to target surgical removal of these subclinical lesions i.e., Wire marker,..

Published: 19/07/2016
Authors: Jois RHS, Harris O,

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Breast cancer recurrence after ROLL lumpectomy

​ Background Very few literatures are available on the long term outcomes after Radioguided Occult Lesion Localisation (ROLL) guided lumpectomy for non palpable invasive breast cancer. We previously published a recurrence of 1.9% with median follow up of 33 months. This is the first observation reporting after a Ten year experience with ROLL...

Published: 19/07/2016
Authors: Jois RHS, Carini S, Harris O, Thind R, Desmond S, Ray A, Chagla LS, Bulgasim N,

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Pathologic Response of Breast Cancer

​ Background:  Neo-adjuvant chemotherapy is being increasingly used for breast cancer. MRI is used for assessing tumour response. Literature on correlation of pathologic response and MRI response is scanty. Aim:  Can a pre-operative MRI predict pathologic response of breast cancer to neo-adjuvant chemotherapy? Methods:  A consecutive series of patients with invasive..

Published: 19/07/2016
Authors: , Jois RHS, Harris O, Pennick M

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ROLL failure rates

​ Background:  We have used Radioisotope Occult Lesion Localization (ROLL) of breast lesions at our unit since 2002. Literature reports failure rates of 4 - 10% for Wire Guided Localisation (WGL). Ours is the first reporting of the difficulties with ROLL (UK) and lessons learnt from it. Method:  A consecutive series of patients underwent..

Published: 19/07/2016
Authors: , Carini S, Harris O, Thind R, Desmond S, Jois RHS

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Impalpable Breast Cancer

​ Background:  The detection of impalpable breast cancer lesions is on the rise due to mass population screening. Radio-guided occult lesion localisation (ROLL) has recently been used in the management of early lesions while sentinel lymph node biopsy (SLNB) has been used to detect occult lymph node metastases. In order to..

Published: 19/07/2016
Authors: Herbert J, , Chagla LS, Desmond S, Galea M, Harris O, Ray A, Thind R, Jois RHS

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Sentinel lymph node biopsy

​ Background:  Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..

Published: 19/07/2016
Authors: Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S,

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Secondary Breast Cancers

​ Background:  Occurrence of metastatic disease to breast (secondary breast cancer) in both women and men is rare, constituting 0.5-6% of breast malignancy. In addition to systematic history taking and clinical examination, early diagnosis of secondary breast cancer demands vigilance by radiologists to distinguish subtle disparities between much commoner primary breast..

Published: 19/07/2016
Authors: Kulkarni T, , Jois RHS, Harris O, Thind R

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ROLL Lumpectomy

​Background  Occult breast lesions are being successfully targeted by means of Radioactive-guided Occult Lesion Localization (ROLL). Several reports demonstrate suitability of ROLL technique to excise non-palpable breast lesions with immediate advantages. Aim  Evaluation of long-term outcomes after ROLL guided lumpectomy for early breast cancer. Materials and methods  A consecutive series..

Published: 19/07/2016
Authors: , Chagla LS, Desmond S, Harris O, Poonawala S, Thind R, Jois RHS

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Prediction of Non Sentinel Nodal Metastases After Positive Sentinel Lymph Node Biopsy for Early Breast Cancer – Burney Breast Unit Experience

Background: Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..

Published: 19/07/2016
Authors: Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S,

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Southport and Ormskirk Hospital Staff - Publications pre April 2024

St Helens Primary and Community Staff

Knowsley Primary and Community Staff

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Halton Primary and Community Staff

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North West Boroughs Community Health Staff

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