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Research Development

Staff Publications

 Small purple icon of a book with a magnifying glass on top  Staff Publications

Find out what your colleagues have been writing. This section features articles published by staff working for St Helens and Knowsley Teaching Hospitals and Halton, Knowsley and St Helens community staff.

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Mersey and West Lancashire Teaching Hospitals Staff

St Helens and Knowsley Hospital Staff - Publications pre April 2024

A European, Observational Study of Endocrine Therapy Administration in Patients With an Initial Diagnosis of Hormone Receptor-Positive Advanced Breast Cancer

Background: Despite guideline recommendations, reports suggest that a proportion of patients with hormone receptor (HR)-positive locally advanced or metastatic breast cancer (LA/MBC) might not receive endocrine therapy. The aims of this study were to estimate the proportion of postmenopausal patients with an initial (primary) diagnosis of HR-positive LA/..

Published: 02/01/2018
Authors:

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Simple reconstructive techniques for conservative breast cancer surgery

Background Patients undergoing breast conservation surgery (BCS) for cancer may benefit with the defect reconstruction using simple techniques to obtain optimal cosmetic & oncological outcome. Aim To determine feasibility simple oncoplastic level 2 reconstruction as a day case. Material and Methods A prospective series of patients eligible for BCS & likely to have..

Published: 25/04/2017
Authors: Jois RHS,

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Beyond

​The progress in scientific and medical knowledge has been fascinating over the last few decades and has had a noticeable impact on the most recent clinical practice. However, not every patient benefits from this progress in the same way; European and North American data are there to prove how senior..

Published: 23/12/2016
Authors:

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Localization techniques for guided surgical excision of non-palpable breast lesions

​ Background Breast cancer is the most common form of cancer and the second leading cause of death amongst women in Europe. Amongst five invasive cancers per 1000 women detected in screening, 2.7 were < 15 mm in diameter; and others reported that over one third of excised breast lesions were clinically occult. The challenge..

Published: 19/07/2016
Authors: Jois RHS,

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Breast conserving surgery

​ Abstract The increasing incidence of breast cancer and advances in detection of small, impalpable cancers presents increasing challenges for the modern breast surgeon. Accurate localization and excision with adequate oncological margins to reduce loco-regional recurrence rates whilst minimizing volume deficit and maximizing aesthetics remains the “gold standard.” We review the..

Published: 19/07/2016
Authors:

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Pseudoangiomatous stromal hyperplasia

​ INTRODUCTION Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion that can be mistaken for angiosarcoma or fibroadenoma. This rare condition generally tends to present as a palpable mass in premenopausal women which can be seen on mammogram and ultrasound alike. The pathological findings tend to be of a thickening..

Published: 19/07/2016
Authors: Barker D,

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ROLL after neo adjuvant treatment

​ Neo-adjuvant chemo & hormone therapy is very effective in reducing the size of the primary breast cancer: this may result into a substantial response, hence the need to localise a non-palpable lesion. A variety of localisation techniques are used to target surgical removal of these subclinical lesions i.e., Wire marker,..

Published: 19/07/2016
Authors: Jois RHS, Harris O,

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Breast cancer recurrence after ROLL lumpectomy

​ Background Very few literatures are available on the long term outcomes after Radioguided Occult Lesion Localisation (ROLL) guided lumpectomy for non palpable invasive breast cancer. We previously published a recurrence of 1.9% with median follow up of 33 months. This is the first observation reporting after a Ten year experience with ROLL...

Published: 19/07/2016
Authors: Jois RHS, Carini S, Harris O, Thind R, Desmond S, Ray A, Chagla LS, Bulgasim N,

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Pathologic Response of Breast Cancer

​ Background:  Neo-adjuvant chemotherapy is being increasingly used for breast cancer. MRI is used for assessing tumour response. Literature on correlation of pathologic response and MRI response is scanty. Aim:  Can a pre-operative MRI predict pathologic response of breast cancer to neo-adjuvant chemotherapy? Methods:  A consecutive series of patients with invasive..

Published: 19/07/2016
Authors: , Jois RHS, Harris O, Pennick M

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ROLL failure rates

​ Background:  We have used Radioisotope Occult Lesion Localization (ROLL) of breast lesions at our unit since 2002. Literature reports failure rates of 4 - 10% for Wire Guided Localisation (WGL). Ours is the first reporting of the difficulties with ROLL (UK) and lessons learnt from it. Method:  A consecutive series of patients underwent..

Published: 19/07/2016
Authors: , Carini S, Harris O, Thind R, Desmond S, Jois RHS

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​ Huisman, MG; Audisio, RA et al. (2012).  The predictive ability of timed “Up & Go” in oncogeriatric surgical patients . European Journal of Surgical Oncology. 38 (9), 769-70  

Published: 19/07/2016
Authors:

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Impalpable Breast Cancer

​ Background:  The detection of impalpable breast cancer lesions is on the rise due to mass population screening. Radio-guided occult lesion localisation (ROLL) has recently been used in the management of early lesions while sentinel lymph node biopsy (SLNB) has been used to detect occult lymph node metastases. In order to..

Published: 19/07/2016
Authors: Herbert J, , Chagla LS, Desmond S, Galea M, Harris O, Ray A, Thind R, Jois RHS

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Sentinel lymph node biopsy

​ Background:  Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..

Published: 19/07/2016
Authors: Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S,

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ROLL Lumpectomy

​Background  Occult breast lesions are being successfully targeted by means of Radioactive-guided Occult Lesion Localization (ROLL). Several reports demonstrate suitability of ROLL technique to excise non-palpable breast lesions with immediate advantages. Aim  Evaluation of long-term outcomes after ROLL guided lumpectomy for early breast cancer. Materials and methods  A consecutive series..

Published: 19/07/2016
Authors: , Chagla LS, Desmond S, Harris O, Poonawala S, Thind R, Jois RHS

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Prediction of Non Sentinel Nodal Metastases After Positive Sentinel Lymph Node Biopsy for Early Breast Cancer – Burney Breast Unit Experience

Background: Sentinel lymph node biopsy (SLNB) is an established method of assessing axillary node status in women with early breast cancer. The primary aim of SLNB is to understand lymph node status with minimal morbidity. Current practice is to offer completion axillary clearance for those women with metastases in sentinel..

Published: 19/07/2016
Authors: Galea M, Jois RHS, Swaminathan V, Chagla LS, Thind R, Harris O, Desmond S,

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St Helens Community Staff

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Knowsley Community Staff

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Halton Community Staff

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North West Boroughs Community Health Staff

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